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Complement Receptor Deficiency Information

A complement receptor is a receptor of the complement system, a part of the mediated innate immune system. Complement receptors are responsible for detecting pathogens by mechanisms not mediated by antibodies. Complement activity is not antigen sensitive, but can be triggered by specific antigens. Therefore complement (a group of proteins in the serum that help achieve phagocytosis and lysis of antigens) is also part of the humoral immune system.

Contents

Complement receptors

Types include:

CR # Name CD
CR1 - CD35
CR2 - CD21
CR3 Macrophage-1 antigen or "integrin alphaMbeta2" CD11b+CD18
CR4 Integrin alphaXbeta2 or "p150,95" CD11c+CD18
- C3a receptor -
- C5a receptor CD88

Clinical significance

Defects in these receptors can be associated with disease.[1]

See also

References

  1. ^ "Complement Receptor Deficiency: eMedicine Dermatology". http://emedicine.medscape.com/article/1051238-overview. Retrieved 2010-12-07.

External links

· · Proteins: complement system (C, L, A)
Activators/enzymes
Early

C: C1Q/C1R/C1S - C4 (C4a) - C2

L: MASP1/MASP2 - MBL

A: Factor B - Factor D - Factor P/Properdin
Middle

C3 (C3a, C3b/iC3b) - C5 (C5a)

C3-convertase - C5-convertase
Late MAC (C6, C7, C8, C9)
Inhibitors

CLA: C1-inhibitor - Decay-accelerating factor/CD59 - Factor I

CL: C4BP

A: Factor H
Complement receptors CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a)

: LMC

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, drug(/)
· · Innate immune system: Pattern recognition receptors
Membrane-bound_PRRs Toll-like receptor · Mannose receptor · Formyl peptide receptor · Scavenger receptor
Cytoplasmic_PRRs Toll-like receptor · NOD-like receptor · Scavenger receptor
Secreted_PRRs Complement receptor · Collectin
Other/ungrouped Immunophilins (Cyclophilin)

: MYL

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///, /,

drug (//), ,

Categories: Complement system

 

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