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Congenital Hemolytic Anemia Information

Congenital hemolytic anemia (or hereditary hemolytic anemia) refers to hemolytic anemia which is primarily due to congenital disorders.[1]

Types

Basically classified by causative mechanism , types of congenital hemolytic anemia include:

See also

References

  1. ^ Rahman SA, Jamal CY (June 2002). "Congenital hemolytic anemia in Bangladesh: types and clinical manifestations". Indian Pediatr 39 (6): 574–7. PMID 12084953.
  2. ^ medconditions.net > Hemolytic Congenital, Nonspherocytic Anemia Definition Retrieved April 15, 2011
  3. ^ Shah A (November 2004). "Hemoglobinopathies and other congenital hemolytic anemia". Indian J Med Sci 58 (11): 490–3. PMID 15567909.
· · Pathology: hematology · hematologic diseases of RBCs and megakaryocytes / MEP (D50-69,74, 280-287)
Red blood cells
↑
Poly- cythemia Polycythemia vera
↓
Anemia
Nutritional

Micro-: Iron deficiency anemia (Plummer-Vinson syndrome)

Macro-: Megaloblastic anemia (Pernicious anemia)
Hemolytic (mostly Normo-)
Hereditary

enzymopathy: G6PD · glycolysis (PK, TI, HK)

hemoglobinopathy: Thalassemia (alpha, beta, delta) · Sickle-cell disease/trait · HPFH

membrane: Hereditary spherocytosis (Minkowski-Chauffard syndrome) · Hereditary elliptocytosis (Southeast Asian ovalocytosis) · Hereditary stomatocytosis
Acquired

Autoimmune (WAHA, CAD, PCH)

membrane (PNH)

MAHA · TM (HUS)

Drug-induced autoimmune · Drug-induced nonautoimmune

Hemolytic disease of the newborn
Aplastic (mostly Normo-)

Hereditary: Fanconi anemia · Diamond–Blackfan anemia

Acquired: PRCA · Sideroblastic anemia · Myelophthisic
Blood tests MCV (Normocytic, Microcytic, Macrocytic) · MCHC (Normochromic, Hypochromic)
Other Methemoglobinemia · Sulfhemoglobinemia · Reticulocytopenia
Coagulation/ coagulopathy
↑
Hyper- coagulability primary: Antithrombin III deficiency · Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden · Hyperprothrombinemia acquired:Thrombocytosis (essential) · DIC (Congenital afibrinogenemia, Purpura fulminans) · autoimmune (Antiphospholipid)
↓
Hypo- coagulability
Thrombocytopenia

Thrombocytopenic purpura: ITP (Evans syndrome) · TM (TTP)

Heparin-induced thrombocytopenia · May-Hegglin anomaly
Platelet function adhesion (Bernard–Soulier syndrome) · aggregation (Glanzmann's thrombasthenia) · platelet storage pool deficiency (Hermansky–Pudlak syndrome, Gray platelet syndrome)
Clotting factor Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand disease • Hypoprothrombinemia/II · XIII · Dysfibrinogenemia

: MYL

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drug (//), ,

Categories: Hematology | Blood disorders | Anemias

 

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