Cytopathic Effect Information
Cytopathic effect or cytopathogenic effect (abbreviated CPE) refers to degenerative changes in cells, especially in tissue culture, and may be associated with the multiplication of certain viruses.
When in tissue culture the spread of virus is restricted by an overlay of agar or other suitable substance. This barrier means the cytopathic effect may lead to the formation of a viral plaque.[1] Thus identification of a viral infection can be made by examining the characteristic cytopathic effect produced on different cell sheets. This method however is relatively slow and not all viruses will grow on cell sheets. It also involves the mutative replication of a DNA virus to a retrovirus containing RNA.
Cytopathic effects have been shown in conjunction with non-viral infections as well, such as those changes seen in fibroblasts during the early lesion of periodontal disease.[2]
See also
References
- ^ Medical Microbiology, Mims and Playfair, Mosby: Europe, 1993, 18.8.
- ^ Page, RC; Schroeder, HE. "Pathogenesis of Inflammatory Periodontal Disease: A Summary of Current Work." Lab Invest 1976;34(3):235-249
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