Indanylaminopropane Information

5-(2-Aminopropyl)-2,3-dihydro-1H-indene (5-APDI), also known as indanylaminopropane (IAP) and, incorrectly, as indanylamphetamine,^[1] is an entactogen and psychedelic drug of the amphetamine family.^[2][3] It has been sold by online vendors through the internet and has been encountered as a designer drug since 2003,^[1][4][5] but its popularity has diminished in recent years.

5-APDI acts as a potent and weakly selective serotonin releasing agent (SSRA) with IC₅₀ values of 82 nM, 1,848 nM, and 849 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine, respectively.^[2][3] It fully substitutes for MBDB but not amphetamine in trained animals, though it does produce disruption for the latter at high doses.^[2]

Anecdotal reports suggest that 5-APDI is considerably less stimulating and euphoric than related compounds like MDMA.^[4][5] However, in combination with amphetamine, it is said to be virtually indistinguishable from MDA by recreational users.^[4][5]

See also

• 5-MAPDI
• 3,4-Dimethylmethcathinone
• 5-APDB
• 6-APB
• 6-APDB
• 5-(2-Aminopropyl)indole
• DFMDA
• Ethylenedioxymethamphetamine
• Naphthylaminopropane
• Tetralinylaminopropane

References

1. ^ ^{a b} Casale JF, McKibben TD, Bozenko JS, Hays PA (2005). "Characterization of the "Indanylamphetamines"". Microgram Journal 3 (1–2): 3–10. http://www.usdoj.gov/dea/programs/forensicsci/microgram/journal_v3/mj05_v3_pg1.html.
2. ^ ^{a b c} Monte AP, Marona-Lewicka D, Cozzi NV, Nichols DE (November 1993). "Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine". Journal of Medicinal Chemistry 36 (23): 3700–6. doi:10.1021/jm00075a027. PMID 8246240.
3. ^ ^{a b} Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE (March 1998). "Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA)". Journal of Medicinal Chemistry 41 (6): 1001–5. doi:10.1021/jm9705925. PMID 9526575.
4. ^ ^{a b c} "Bluelight Forums - The Big and Dandy Indanylaminopropane (IAP) Thread". http://www.bluelight.ru/vb/showthread.php?t=97013.
5. ^ ^{a b c} "Erowid Experience Vaults - Indanylaminopropane (IAP)". http://www.erowid.org/experiences/subs/exp_IAP.shtml.

External links

• The Vaults of Erowid - Indanylaminopropane
• Erowid Experience Vaults - Indanylaminopropane
• Bluelight Forums - The Big and Dandy Indanylaminopropane (IAP) Thread
• Rhodium - Synthesis of Indanylaminopropane
• MadMax - Illustrated Synthesis of Indanylaminopropane

Categories:

• Entactogens and Empathogens
• Indanes

Related 'Indanylaminopropane' Searches: