Interleukin-4 Receptor Information
Interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.[1]
See also
Interactions
Interleukin-4 receptor has been shown to interact with SHC1.[2][3]
References
- ^ "Entrez Gene: IL4R interleukin 4 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3566.
- ^ Ikizawa, K; Yanagihara Y (Feb. 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. (UNITED STATES) 268 (1): 54–9. doi:10.1006/bbrc.2000.2080. ISSN 0006-291X. PMID 10652211.
- ^ Kashiwada, M; Giallourakis C C, Pan P Y, Rothman P B (Dec. 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. (United States) 167 (11): 6382–7. ISSN 0022-1767. PMID 11714803.
Further reading
| · · PDB gallery |
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1iar: INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX
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External links
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Proteins: clusters of differentiation (see also list of human clusters of differentiation) |
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CD1 (a-c, 1A, 1D, 1E) · CD2 · CD3 (γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 (a) · CD9 · CD10 · CD11 (a, b, c) · CD13 · CD14 · CD15 · CD16 (A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 (A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 (a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 (a, b, c, d, e, f) · CD50
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| 51-100 |
CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 (E, L, P) · CD63 · CD64 (A, B, C) · CD66 (a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 (a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 (a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100
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| 101-150 |
CD101 · CD102 · CD103 · CD104 · CD105 · CD106 · CD107 (a, b) · CD108 · CD109 · CD110 · CD111 · CD112 · CD113 · CD114 · CD115 · CD116 · CD117 · CD118 · CD119 · CD120 (a, b) · CD121 (a, b) · CD122 · CD123 · CD124 · CD125 · CD126 · CD127 · CD129 · CD130 · CD131 · CD132 · CD133 · CD134 · CD135 · CD136 · CD137 · CD138 · CD140b · CD141 · CD142 · CD143 · CD144 · CD146 · CD147 · CD148 · CD150
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| 151-200 |
CD151 · CD152 · CD153 · CD154 · CD155 · CD156 (a, b, c) · CD157 · CD158 (a, d, e, i, k) · CD159 (a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 (a, b) · CD168 · CD169 · CD170 · CD171 · CD172 (a, b, g) · CD174 · CD177 · CD178 · CD179 (a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200
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| 201-250 |
CD201 · CD202b · CD204 · CD205 · CD206 · CD207 · CD208 · CD209 · CDw210 (a, b) · CD212 · CD213a (1, 2) · CD217 · CD218 (a, b) · CD220 · CD221 · CD222 · CD223 · CD224 · CD225 · CD226 · CD227 · CD228 · CD229 · CD230 · CD233 · CD234 · CD235 (a, b) · CD236 · CD238 · CD239 · CD240CE · CD241 · CD243 · CD244 · CD246 · CD247- CD248 · CD249
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| 251-300 |
CD252 · CD253 · CD254 · CD256 · CD257 · CD258 · CD261 · CD262 · CD264 · CD265 · CD266 · CD267 · CD268 · CD269 · CD271 · CD272 · CD273 · CD274 · CD275 · CD276 · CD278 · CD279 · CD280 · CD281 · CD282 · CD283 · CD284 · CD286 · CD288 · CD289 · CD290 · CD292 · CDw293 · CD294 · CD295 · CD297 · CD298 · CD299
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| 301-350 |
CD300A · CD301 · CD302 · CD303 · CD304 · CD305 · CD306 · CD307 · CD309 · CD312 · CD314 · CD315 · CD316 · CD317 · CD318 · CD320 · CD321 · CD322 · CD324 · CD325 · CD326 · CD328 · CD329 · CD331 · CD332 · CD333 · CD334 · CD335 · CD336 · CD337 · CD338 · CD339 · CD340 · CD344 · CD349 · CD350
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Cytokine receptors |
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| Chemokine receptor
(GPCRs) |
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| TNF receptor |
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| JAK-STAT |
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Type I
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γ-chain
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Interleukin receptors (IL2R/IL2RA/IL2RB/IL15R, IL4R/IL13R/IL13RA1/IL13RA2, IL7R/IL7RA, IL9R, IL21R)
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β-chain
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Interleukin receptors (IL3R/IL3RA, IL5R/IL5RA) · GM-CSF
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gp130
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Interleukin receptors (IL6RA, 11/IL11RA, 27/IL27RA) · OSMR · LIFR · CNTFR
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IL12RB1
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Interleukin receptors (IL12R/IL12RB1/IL12RB2, IL23R23)
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Other
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other CSF receptors (EPO, G-CSF, Thrombopoietin)
hormone receptor: GH · prolactin
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Type II
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Interleukin receptors (IL10R/IL10RA/IL10RB/IL22R/IL22RA2, IL20R/IL20RA/IL20RB, IL28R) · Interferon receptors (-α/β/IFNAR1/IFNAR2, -γ/IFNGR1/IFNGR2)
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| Ig superfamily |
CSF1 · KIT · IL1 (IL1R1, IL1R2) · IL18R/IL18R1
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| IL-17 family |
IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)
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| S/T |
TGF-beta (TGFBR1, TGFBR2)
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Categories: Human proteins | Cytokine receptors | Type I cytokine receptors | Clusters of differentiation |
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