hidden pixel

Lestaurtinib Information

Lestaurtinib (rINN, codenamed CEP-701) is a tyrosine kinase inhibitor structurally related to staurosporine, and is being developed by Cephalon.

It is an inhibitor of FLT3[1], JAK2[2], TrkA, TrkB and TrkC.[3]

Uses

It is undergoing research for the treatment of acute myelogenous leukemia (AML) and myeloproliferative disorders.

As of 2009[update], it is in Phase II clinical trials for AML and Phase II clinical trials for myeloproliferative disorders.[4][5]

See also

References

  1. ^ Knapper S, Burnett AK, Littlewood T, et al. (November 2006). "A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy". Blood 108 (10): 3262–70. doi:10.1182/blood-2006-04-015560. PMID 16857985. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=16857985.
  2. ^ Hexner EO, Serdikoff C, Jan M, et al. (June 2008). "Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders". Blood 111 (12): 5663–71. doi:10.1182/blood-2007-04-083402. PMC 2424161. PMID 17984313. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=17984313.
  3. ^ Revill, P., Serradell, N., Bolos, J., Rosa, E. (2007). "Lestaurtinib". Drugs of the Future 32 (3): 215. doi:10.1358/dof.2007.032.03.1084137.
  4. ^ "Oncology pipeline Oct 2009". http://www.cephalon.com/fileadmin/media/downloads/Cephalon_Oncology_Pipeline_Fact_Sheet_FINAL_10_2009.pdf.
  5. ^ "Trials of Lestaurinib". http://clinicaltrials.gov/ct2/results?term=Lestaurtinib.
Targeted therapy / extracellular chemotherapeutic agents/antineoplastic agents (L01)
CI monoclonal antibodies ("-mab")
Receptor tyrosine kinase
Others for solid tumors
Leukemia/lymphoma myeloid: CD33 (Gemtuzumab)
Tyrosine-kinase inhibitors ("-nib")
Receptor tyrosine kinase
Non-receptor EML4-ALK (Crizotinib)
Other

: NEO

,

, ,

drug (//)
This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

Categories:

 

The above information uses material from Wikipedia and is licensed under the GNU Free Documentation License.
Some facts may not have been fully verified for accuracy. [Disclaimers]
This page was last archived by our server on Sat Jun 2 20:30:44 2012.
Displaying this page or its contents does not use any Wikimedia Foundation's resources.
The owners of this site proudly support the Wikimedia Foundation.

More Information Results for "Lestaurtinib"
[Hide]▼
'Lestaurtinib' Images
[Hide]▲