The myeloblast is a unipotent stem cell, which will differentiate into one of the effectors of the Granulocyte series.

Contents

• 1 Origin
• 2 Location in the body
• 3 Structure
• 4 Function
• 5 Pathology
• 6 See also
• 7 References
• 8 External links

Origin

These cells descend from the primitive reticulum cells, which are found in the stroma of the marrow. There is also an intermediate phase between the myeloblast and these primitive reticulum cell, namely the hemocytoblast. At this time several developing blood cell lines are available, like erythropoiesis and thrombopoiesis. The granulopoiesis is regulated by humoral agents, like Colony Stimulating Factor and Interleukin 3.

Location in the body

The myeloblasts reside extravascularly in the marrow. The hematopoiesis takes place in the extravascular cavities between the sinuses of the marrow. The wall of the sinuses is composed with two different types of cells, the endothelial cells and the adventitial reticular cells. The hemopoietic cells are aligned in cords or wedges between these sinuses, the myeloblasts and other granular progenitors are concentrated in the subcortical regions of these hemopoietic cords.

Neutrophil Information (Neutrophils, Cells, Cell, Cfu ...
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Leukocytes Information (Cells, Cfu, Granules, Blood ...
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