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Normochromic Information

Normochromic is a form of anemia in which the concentration of hemoglobin in the red blood cells is within the standard range. However, there are insufficient numbers of red blood cells. This includes: aplastic, posthemorrhagic, and hemolytic anemias and anemia of chronic disease.

synonymous with normocytic anemia

Pathology: hematology · hematologic diseases of RBCs and megakaryocytes / MEP (D50-69,74, 280-287)
Red blood cells
↑
Poly- cythemia Polycythemia vera
↓
Anemia
Nutritional

Micro-: Iron deficiency anemia (Plummer-Vinson syndrome)

Macro-: Megaloblastic anemia (Pernicious anemia)
Hemolytic (mostly Normo-)
Hereditary

enzymopathy: G6PD · glycolysis (PK, TI, HK)

hemoglobinopathy: Thalassemia (alpha, beta, delta) · Sickle-cell disease/trait · HPFH

membrane: Hereditary spherocytosis (Minkowski-Chauffard syndrome) · Hereditary elliptocytosis (Southeast Asian ovalocytosis) · Hereditary stomatocytosis
Acquired

Autoimmune (WAHA, CAD, PCH)

membrane (PNH)

MAHA · TM (HUS)

Drug-induced autoimmune · Drug-induced nonautoimmune

Hemolytic disease of the newborn
Aplastic (mostly Normo-)

Hereditary: Fanconi anemia · Diamond–Blackfan anemia

Acquired: PRCA · Sideroblastic anemia · Myelophthisic
Blood tests MCV (Normocytic, Microcytic, Macrocytic) · MCHC (Normochromic, Hypochromic)
Other Methemoglobinemia · Sulfhemoglobinemia · Reticulocytopenia
Coagulation/ coagulopathy
↑
Hyper- coagulability primary: Antithrombin III deficiency · Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden · Prothrombin G20210A acquired:Thrombocytosis (essential) · DIC (Congenital afibrinogenemia, Purpura fulminans) · autoimmune (Antiphospholipid)
↓
Hypo- coagulability
Thrombocytopenia

Thrombocytopenic purpura: ITP (Evans syndrome) · TM (TTP)

Heparin-induced thrombocytopenia · May-Hegglin anomaly
Platelet function adhesion (Bernard–Soulier syndrome) · aggregation (Glanzmann's thrombasthenia) · platelet storage pool deficiency (Hermansky–Pudlak syndrome, Gray platelet syndrome)
Clotting factor Hemophilia (A/VIII, B/IX, C/XI) • von Willebrand disease • Hypoprothrombinemia/II · XIII · Dysfibrinogenemia

: MYL

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